Neural Development and Stem Cells (Contemporary Neuroscience)

by Mahendra S. Rao

Publisher: Humana Press

Written in English
Cover of: Neural Development and Stem Cells (Contemporary Neuroscience) | Mahendra S. Rao
Published: Pages: 468 Downloads: 763
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Subjects:

  • Embryology,
  • Neurology & clinical neurophysiology,
  • Medical / Nursing,
  • Medical,
  • Neuroscience,
  • Medical / Neuroscience,
  • Life Sciences - Biology - Molecular Biology,
  • Developmental neurobiology,
  • Stem cells
The Physical Object
FormatHardcover
Number of Pages468
ID Numbers
Open LibraryOL9504138M
ISBN 101588294811
ISBN 109781588294814

  The proper functioning of neural stem cells is critical for human development and health. When neural crest biology fails, various birth defects and illnesses can result, such as cleft lip or.   Transplantation of neural stem cells (NSCs) has been proposed as an alternative novel therapy to replace damaged neural circuitry after ischemic stroke onset. Nonetheless, albeit the potential of these cells for stroke therapy, many critical challenges are yet to be overcome to reach clinical applications. The major limitation of the NSC-based therapy is its inability to retain most of the.   Through which process do neural stem cells become nerve cells? Neural stem cells become neurons in a process called neurogenesis (from the greek, birth of neuron). This occurs mostly during embryonic development and gives rise to the wide variety of neurons in the brain. In some cases, neurogenesis continues after birth, into adult life. Background: Velvet antler polypeptides (VAPs), which are derived from the antler velvets, have been reported to maintain survival and promote growth and differentiation of neural cells and, especially the development of neural tissues. This study was designed to explore the influence of VAPs on neural stem cells in vitro derived from embryonic rat brain.

  Neural stem/progenitor cells (NSPCs) have a potential to treat various neurological diseases, such as Parkinson's Disease, Alzheimer's Disease, and Spinal Cord Injury. However, the limitation of NSPC sources and the difficulty to maintain their stemness or to differentiate them into specific therapeutic cells are the main hurdles for clinical.   Studying how stem cells maintain genomic stability can help advance the safe use of stem cells and understand the pathogenesis of related .   Stem cells are cells that have not yet chosen a specialized fate, such as to become a neuron, or white blood cell. Possible link to evolutionary development of the neural .

Neural Development and Stem Cells (Contemporary Neuroscience) by Mahendra S. Rao Download PDF EPUB FB2

Authoritative and up-to-date, Neural Development and Stem Cells, 3rd Edition provides neuroscientists with a handy guide to stem cells in the nervous system, tracing with great clarity the development of stem cells from differentiation to neurons, astrocytes, and oligodendrocytes.

Additional information about our understanding of the differentiation of pluripotent stem cells into the various neural cell types has been included.

Particular attention has been focused on the chapters describing retinal epithelium and neuroglial differentiation, as these cells are currently being delivered in early phase clinical trials.

Developing the second edition of Neural Development and Stem Cells was neces- tated by the rapid increase in our knowledge of the development of the nervous Neural Development and Stem Cells book.

It has become increasingly clear that stem cells are a heterogeneous population that changes extensively during development. Developing the second edition of Neural Development and Stem Cells was neces- tated by the rapid increase in our knowledge of the development of the nervous system.

It has become increasingly clear that stem cells are a heterogeneous population that changes extensively during development.

PerhapsBrand: Humana Press. GET THIS BOOK Neural Development and Stem Cells. Developing the second edition of Neural Development and Stem Cells was neces- tated by the rapid increase in our knowledge of the development of the nervous system.

It has become increasingly clear that stem cells are a heterogeneous population that changes extensively during development.4/5(21).

Special attention is paid to the derivation of neural cells from embryonic stem cells and induced pluripotent stem cells. Authoritative and up-to-date, Neural Development and Stem Cells, 3rd Edition provides neuroscientists with a handy guide to stem cells in the nervous system, tracing with great clarity the development of stem cells from.

On the other side, many problems arise when stem cells encounter the mature brain parenchyma, still hampering the development of efficacious therapeutic approaches with endogenous or exogenously-delivered neural stem cells.

This book tries to make the point on these extremely promising, yet unresolved, by: 7. The book also includes chapters on induced pluripotent stem cells (iPSCs), the methods used to obtain them, and a review of the ethical challenges associated with stem cell research.

For each region, the book provides a description of its neurogenic niche, cellular and molecular biology, and information on the neurons’ contribution to normal. Yang D.

Teng, Evan Y. Snyder, in Principles of Regenerative Medicine, Definition. Neural Stem Cells (NSCs) are the most primordial and uncommitted cells of the nervous system, and are believed to give rise to the vast Neural Development and Stem Cells book of more specialized cells of the CNS and peripheral nervous system (PNS).

To be considered a “neural stem cell,” in contrast to a “progenitor” cell (i.e. This book is a collective work of international experts in the neural stem cell field. The book incorporates the characterization of embryonic and adult neural stem cells in both invertebrates and vertebrates.

It highlights the history and the most advanced discoveries in neural stem cells, and summarizes the mechanisms of neural stem cell development. In particular, this book provides Cited by: 4.

In early neural development, when the patterning of the nervous system is established, neural stem cells are called neuroepithelial cells; they are situated among other neuroepithelial cells and they are exposed to various signals such as retinoic acid, sonic hedgehog and fibroblast growth factors.

The book also includes chapters on induced pluripotent stem cells (iPSCs), the methods used to obtain them, and a review of the ethical challenges associated with stem cell research. For each region, the book provides a description of its neurogenic niche, cellular and molecular biology, and information on the neurons’ contribution to normal Price: $ As novel drug delivery agents, neural stem cells also show promise in killing gliomas and other cancers.

To facilitate research resulting from these advances, a large and diverse market has emerged for neural stem cell products and services. One thriving component of the neural stem cell marketplace is the market for research reagents/supplies.

ISBN: OCLC Number: Description: x, pages: illustrations ; 26 cm. Contents: Defining Neural Stem Cells and Their Role in Normal Development of the Nervous System / Sally Temple --Neural Stem Cells in the Adult Brain: Implications of their glial characteristics / Daniel A.

Lim and Arturo Alvarez-Buylla --Cellular and. Developing the second edition of Neural Development and Stem Cells was neces- tated by the rapid increase in our knowledge of the development of the nervous system.

It has become increasingly clear that stem cells are a heterogeneous population that changes extensively during development. Perhaps the most important advance in our understanding of stem cell behavior has been the realization Book Edition: 2nd Ed.

Cambridge (MA): Harvard Stem Cell Institute; Top results in this book Improving and Accelerating Therapeutic Development for Nervous System Press (US); Feb 6. Top results in this book Table of Contents.

Select item Transcriptional Control of Neural Crest Development. Nelms BL, Labosky PA. San Rafael (CA): Morgan. Written by world-renowned scientists in the field, Neural Stem Cells in Development, Adulthood and Disease presents cutting-edge studies of interest to both established neurogenesis researchers and readers with general interests in nervous system science.

It is an authoritative addition to the Stem Cell Biology and Regenerative Medicine series. Get this from a library.

Neural development and stem cells. [Mahendra S Rao;] -- Developing the second edition of Neural Development and Stem Cells was neces- tated by the rapid increase in our knowledge of the development of the nervous system.

It has become increasingly clear. In addition to demonstrating the stem cell nature of a considerable fraction of neural crest cells, in vitro studies also revealed environmental signals regulating fate decisions in NCSCs (reviewed in Le Douarin et al., ; Sieber-Blum, ; Sommer, ).In principle, two possible modes of action have been proposed for such factors: a specific factor could selectively favor the development.

A comprehensive resource on neural crest cells for researchers studying cell biology, developmental biology, stem cells and neurobiology, Neural Crest Cells: Evolution, Development and Disease provides foundational information needed for students, practicing physicians and dentists treating patients with craniofacial Medical Book.

Neural stem cells offer a valuable model system for delineating the cellular and developmental processes in normal and diseased states of the central nervous system. In particular, neural stem cells have huge potential in regenerative medicine, owing to Pages: Neural Crest Cells: Evolution, Development and Disease summarizes discoveries of historical significance and provides in-depth, current analyses of the evolution of neural crest cells, their contribution to embryo development, and their roles in disease.

In addition, prospects for tissue engineering, repair and regeneration are covered, offering a timely synthesis of the current knowledge.

The study, published in Stem Cell Research, provides new insight into the formation of neural crest cells and outlines transient prospective stages in their also shows the neural. The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body.

These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the.

Radial migration. Neuronal precursor cells proliferate in the ventricular zone of the developing neocortex, where the principal neural stem cell is the radial glial first postmitotic cells must leave the stem cell niche and migrate outward to form the preplate, which is destined to become Cajal-Retzius cells and subplate neurons.

These cells do so by somal translocation. Neural Progenitor Cells: Methods and Protocols is a collection of practical articles describing techniques used to study neural stem and progenitor cells. The volume also highlights the promise of stem cell-based therapeutic applications for CNS disorders.

The study, published in Stem Cell Research, provides new insight into the formation of neural crest cells and outlines transient prospective stages in their development. It also shows the neural.

the neural crest cells can be distinguished from the cells of the neural primordium, the cells of the neural tube, and also from the cells of the superficial ectoderm, by the fact that they express a certain number of genes particularly transcription factors which are listed here.

Mohan C. Vemuri, Ph.D.,MBA is director of stem cell research and development in the Life Technologies division of Invitrogen & Applied Biosystems. The author of designs of peer-reviewed articles in the field, Dr.

Vemuri is also a co-editor of three books on stem cells and stem cell cultures. Stem and progenitor cells exhibit diversity in early brain development that likely contributes to later neural complexity in the adult cerebral cortex, this according to.

Author summary Mitosis is a fundamental process that segregates replicated chromosomes into daughter cells, allowing organ growth and development in multicellular organisms.

To properly distribute the genetic material, the mitotic spindle, an organelle consisting of extended microtubules, microtubule motors, and additional microtubule-associated proteins needs to be built in .During development, neural stem cells serve as the ultimate origin of all three major cell types in the mature CNS, namely neurons, oligodendrocytes and astrocytes.

These cells are further specified to a huge variety of subtypes at topologically defined positions and specific developmental time windows. Neurogenesis is the process by which neurons are created.

This process is most active during pre-natal development when neurogenesis is responsible for populating the growing brain. Thus, the difference between neural stem and neural progenitor cells is that neural stem cells are self-renewing, while neural progenitor cells can only undergo a limited number of replication cycles.